Review



3d biomimetic model  (BioMimetic Therapeutics)

 
  • Logo
  • About
  • News
  • Press Release
  • Team
  • Advisors
  • Partners
  • Contact
  • Bioz Stars
  • Bioz vStars
    • 90
      Buy from Supplier

    Structured Review

    BioMimetic Therapeutics 3d biomimetic model
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    3d Biomimetic Model, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pmc12187138-135-13-27?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    3d biomimetic model - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension"

    Article Title: TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    Journal: eLife

    doi: 10.7554/eLife.104894

    High-resolution representative image of collagen gels used for contractility experiments without a circle around the periphery of the gel.
    Figure Legend Snippet: High-resolution representative image of collagen gels used for contractility experiments without a circle around the periphery of the gel.

    Techniques Used:

    ( A ) Representative longitudinal 24-well plate scans of collagen type I hydrogels seeded with primary TM (pTM) subjected to the different treatments (dashed lines outline size of contracted constructs). ( B ) Longitudinal quantification of hydrogel construct size compared to the control group at the 0 min time point. ( C ) Detailed comparisons between groups at each experimental time point. n = 6 hydrogels/group. One-way ANOVA with Tukey’s multiple comparisons test, data in ( B, C ) show individual data points over mean ± SD. One pTM strain shown: TGFβ2-induced contractility induction, HC-06-mediated rescue of hypercontractility, and GSK101-induced transient (15 min) contraction were consistent across (3/3) pTM strains tested . **p < 0.01, ***p < 0.001, ****p < 0.0001.
    Figure Legend Snippet: ( A ) Representative longitudinal 24-well plate scans of collagen type I hydrogels seeded with primary TM (pTM) subjected to the different treatments (dashed lines outline size of contracted constructs). ( B ) Longitudinal quantification of hydrogel construct size compared to the control group at the 0 min time point. ( C ) Detailed comparisons between groups at each experimental time point. n = 6 hydrogels/group. One-way ANOVA with Tukey’s multiple comparisons test, data in ( B, C ) show individual data points over mean ± SD. One pTM strain shown: TGFβ2-induced contractility induction, HC-06-mediated rescue of hypercontractility, and GSK101-induced transient (15 min) contraction were consistent across (3/3) pTM strains tested . **p < 0.01, ***p < 0.001, ****p < 0.0001.

    Techniques Used: Construct, Control

    Chronic exposure to TGFβ2 induces upregulation of functional TRPV4 channels alongside the autoinhibitory canonical modulator SMAD7. TRPV4-mediated Ca 2+ influx, canonical, and non-canonical TGFβ2 signaling stimulate the Rho/ROCK pathway to augment cytoskeletal contractility and stimulate extracellular matrix (ECM) release. Actomyosin contractility promotes outflow resistance and drives OHT and underpins a vicious feedforward TRPV4-dependent loop that maintains OHT. This figure was created using BioRender.com .
    Figure Legend Snippet: Chronic exposure to TGFβ2 induces upregulation of functional TRPV4 channels alongside the autoinhibitory canonical modulator SMAD7. TRPV4-mediated Ca 2+ influx, canonical, and non-canonical TGFβ2 signaling stimulate the Rho/ROCK pathway to augment cytoskeletal contractility and stimulate extracellular matrix (ECM) release. Actomyosin contractility promotes outflow resistance and drives OHT and underpins a vicious feedforward TRPV4-dependent loop that maintains OHT. This figure was created using BioRender.com .

    Techniques Used: Functional Assay



    Similar Products

    3d biomimetic model  (BioMimetic Therapeutics)
    90
    BioMimetic Therapeutics 3d biomimetic model
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    3d Biomimetic Model, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pmc12187138-135-13-27?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    3d biomimetic model - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    3d biomimetic nasal cavity model  (BioMimetic Therapeutics)
    90
    BioMimetic Therapeutics 3d biomimetic nasal cavity model
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    3d Biomimetic Nasal Cavity Model, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pm40574099-6-2-3?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    3d biomimetic nasal cavity model - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    3d-printed biomimetic nasal models  (BioMimetic Therapeutics)
    90
    BioMimetic Therapeutics 3d-printed biomimetic nasal models
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    3d Printed Biomimetic Nasal Models, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pm40574099-30-7-8?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    3d-printed biomimetic nasal models - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    3d real-scale, biomimetic, and biohybrid model of the blood-brain barrier  (BioMimetic Therapeutics)
    90
    BioMimetic Therapeutics 3d real-scale, biomimetic, and biohybrid model of the blood-brain barrier
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    3d Real Scale, Biomimetic, And Biohybrid Model Of The Blood Brain Barrier, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pm40572410-512-23-17?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    3d real-scale, biomimetic, and biohybrid model of the blood-brain barrier - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    3d-printed biomimetic model  (BioMimetic Therapeutics)
    90
    BioMimetic Therapeutics 3d-printed biomimetic model
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    3d Printed Biomimetic Model, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pm40342273-177-7-8?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    3d-printed biomimetic model - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier
    custom 3d-printed biomimetic model  (BioMimetic Therapeutics)
    90
    BioMimetic Therapeutics custom 3d-printed biomimetic model
    High-resolution representative image of collagen gels used for <t>contractility</t> experiments without a circle around the periphery of the gel.
    Custom 3d Printed Biomimetic Model, supplied by BioMimetic Therapeutics, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/3d+biomimetic+model/pm40342273-85-8-8?v=BioMimetic+Therapeutics
    Average 90 stars, based on 1 article reviews
    custom 3d-printed biomimetic model - by Bioz Stars, 2026-07
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    High-resolution representative image of collagen gels used for contractility experiments without a circle around the periphery of the gel.

    Journal: eLife

    Article Title: TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    doi: 10.7554/eLife.104894

    Figure Lengend Snippet: High-resolution representative image of collagen gels used for contractility experiments without a circle around the periphery of the gel.

    Article Snippet: The present study extends those observations by revealing the TRPV4 -dependence of TM contractility (the agonist GSK101 induced, and the antagonist HC-06 suppressed, contractility in a 3D biomimetic model) and by establishing TRPV4 as an obligatory effector of OHT under physiological (circadian rhythmicity) as well as pathological conditions.

    Techniques:

    ( A ) Representative longitudinal 24-well plate scans of collagen type I hydrogels seeded with primary TM (pTM) subjected to the different treatments (dashed lines outline size of contracted constructs). ( B ) Longitudinal quantification of hydrogel construct size compared to the control group at the 0 min time point. ( C ) Detailed comparisons between groups at each experimental time point. n = 6 hydrogels/group. One-way ANOVA with Tukey’s multiple comparisons test, data in ( B, C ) show individual data points over mean ± SD. One pTM strain shown: TGFβ2-induced contractility induction, HC-06-mediated rescue of hypercontractility, and GSK101-induced transient (15 min) contraction were consistent across (3/3) pTM strains tested . **p < 0.01, ***p < 0.001, ****p < 0.0001.

    Journal: eLife

    Article Title: TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    doi: 10.7554/eLife.104894

    Figure Lengend Snippet: ( A ) Representative longitudinal 24-well plate scans of collagen type I hydrogels seeded with primary TM (pTM) subjected to the different treatments (dashed lines outline size of contracted constructs). ( B ) Longitudinal quantification of hydrogel construct size compared to the control group at the 0 min time point. ( C ) Detailed comparisons between groups at each experimental time point. n = 6 hydrogels/group. One-way ANOVA with Tukey’s multiple comparisons test, data in ( B, C ) show individual data points over mean ± SD. One pTM strain shown: TGFβ2-induced contractility induction, HC-06-mediated rescue of hypercontractility, and GSK101-induced transient (15 min) contraction were consistent across (3/3) pTM strains tested . **p < 0.01, ***p < 0.001, ****p < 0.0001.

    Article Snippet: The present study extends those observations by revealing the TRPV4 -dependence of TM contractility (the agonist GSK101 induced, and the antagonist HC-06 suppressed, contractility in a 3D biomimetic model) and by establishing TRPV4 as an obligatory effector of OHT under physiological (circadian rhythmicity) as well as pathological conditions.

    Techniques: Construct, Control

    Chronic exposure to TGFβ2 induces upregulation of functional TRPV4 channels alongside the autoinhibitory canonical modulator SMAD7. TRPV4-mediated Ca 2+ influx, canonical, and non-canonical TGFβ2 signaling stimulate the Rho/ROCK pathway to augment cytoskeletal contractility and stimulate extracellular matrix (ECM) release. Actomyosin contractility promotes outflow resistance and drives OHT and underpins a vicious feedforward TRPV4-dependent loop that maintains OHT. This figure was created using BioRender.com .

    Journal: eLife

    Article Title: TRPV4 activation by TGFβ2 enhances cellular contractility and drives ocular hypertension

    doi: 10.7554/eLife.104894

    Figure Lengend Snippet: Chronic exposure to TGFβ2 induces upregulation of functional TRPV4 channels alongside the autoinhibitory canonical modulator SMAD7. TRPV4-mediated Ca 2+ influx, canonical, and non-canonical TGFβ2 signaling stimulate the Rho/ROCK pathway to augment cytoskeletal contractility and stimulate extracellular matrix (ECM) release. Actomyosin contractility promotes outflow resistance and drives OHT and underpins a vicious feedforward TRPV4-dependent loop that maintains OHT. This figure was created using BioRender.com .

    Article Snippet: The present study extends those observations by revealing the TRPV4 -dependence of TM contractility (the agonist GSK101 induced, and the antagonist HC-06 suppressed, contractility in a 3D biomimetic model) and by establishing TRPV4 as an obligatory effector of OHT under physiological (circadian rhythmicity) as well as pathological conditions.

    Techniques: Functional Assay